个人简介
个人主页：www.leshimin.org
研究领域：
2022.10 -- 至今: 厦门大学，物理系，教授，博士生导师；
2022.04-2022.09: 厦门大学，物理系，副教授，博士生导师；
2016.02-2022.02: 新加坡国立大学，物理系，博士后研究员 (Research Fellow)；
2010.08-2015.10: 新加坡国立大学，力学生物学研究所，博士；
2006.09-2010.07: 厦门大学，物理系，物理学，学士；
科研基金及项目：
国家级高层次青年引进人才计划；
国家自然科学基金面上项目，2023.01-2026.12，主持；
国家自然科学基金青年项目，2023.01-2025.12，主持；
厦门大学南强青年拔尖人才支持计划（A类）；
厦门大学校长基金，2022.01-2024.12，主持；
代表性文章或专著：
一、通讯（共同通讯）作者文章（*）：
[1]. Y. Wang, J. Ye, X. Liu, Z. Zhang, F. Shang, X. Qi, Y. Zhang, J. Du, H. Sun, J. Xu, H. Chen*, M. Yu*, S. Le*, Mechanically weak and highly dynamic state of mechanosensitive titin Ig domains induced by proline isomerization, Nature Communications 16(1):2771(2025)
[2]. Y. Zhang, Z. Zhang, H. Sun, Z. Xue, Y. Wang, Z. Guo, S. Le*, & H. Chen*, Anomalous Force-Dependent Transition Rates Unveil Dual Pathways in Folding and Unfolding Dynamics of Acyl-coenzyme A Binding Protein, The Journal of Physical Chemistry Letters 16, 2479-2486 (2025)
[3]. Y. Zhang#, J. Du#, X. Liu, F. Shang, Y. Deng, J. Ye, Y. Wang, J.Yan, H. Chen*, M. Yu* & S. Le*, Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification, Nature Communications 15: 6151 (2024)
[4]. J. Xu, H. Sun, Z. Zhang, Z. Guo, S. Le*, H. Chen* , Folding and Misfolding Dynamics of Irisin Protein Revealed by Single-Molecule Magnetic Tweezers , The Journal of Physical Chemistry Letters 15, 11954-11960 (2024)
[5]. Z Xue, H Sun, H Hong, Z Zhang, Y Zhang, Z Guo, S. Le*, H Chen*, Comparative analysis of folding and unfolding dynamics and free-energy landscapes in homologous cold shock proteins with variable thermal stabilities, Physical Review Research 6 (2), 023170 (2024)
[6]. M. Yu, J. Lu, S. Le*, and J. Yan*, Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature, The Journal of Physical Chemistry Letters 12(33), 7914-7920 (2021)
[7]. M. Yu, Z. Zhao, Z. Chen, S. Le*, and J. Yan*, Modulating Mechanical Stability of Heterodimerization Between Engineered Orthogonal Helical Domains, Nature Communications 11: 4476 (2020)
二、第一（共同第一）作者文章（#）：
[1]. S. Le#, M. Yu#, C. Fu#, JA Heier, S Martin, J. Hardin*, J. Yan* , Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction, Proceedings of the National Academy of Sciences 121 (37), e2400654121 (2024)
[2]. M. Yu#, S. Le#, S. Barnett#, Z. Guo, X. Zhong, P. Kanchanawong*, and J. Yan*, Implementing Optogenetic Modulation in Mechanotransduction, Physical Review X 10, 021001 (2020)
[3]. S. Le#, M. Yu#, and J. Yan*, Direct Single-molecule Quantification Reveals Surprisingly High Mechanical Stability of Vinculin--Talin/alpha-Catenin Linkages, Science Advances 5 (12), eaav2720 (2019)
[4]. S. Le#, M. Yu#, and J. Yan*, Phosphorylation Reduces the Mechanical Stability of alpha-catenin/beta-catenin Complex, Angewandte Chemie International Edition 58(51) 18663-18669 (2019)
[5]. M. Yu#, S. Le#, Y. Ammon#, B. Goult, A. Akhmanova*, and J. Yan*, Force-dependent Regulation of KANK1-talin Complex at Focal Adhesions, Nano Letters 19 (9), 5982-5990 (2019)
[6]. S. Le, M. Yu, L. Hovan, Z. Zhao, J. Ervasti, and J. Yan*, Dystrophin as a Molecular Shock Absorber, ACS Nano 12(12):12140-12148 (2018)
[7]. M. Yu#, S. Le#, A. Efremov, X. Zeng, A. Bershadsky, and J. Yan*, Effects of Mechanical Stimuli on Profilin- and Formin-mediated Actin Polymerization, Nano Letters 18 (8), 5239-5247. (2018)
[8]. S. Le, X. Hu, M. Yao, H. Chen, M. Yu, X. Xu, F. Margadant, M. Sheetz*, and J. Yan*, Mechanotransmission and Mechanosensing of Human alpha-actinin 1, Cell Reports 21, 1-10. (2017)
[9]. S. Le#, E. Serrano#, R. Kawamura B. Carrasco, J. Yan*, and J.Alonso*, Bacillus Subtilis DprA and SsbA Promote the Assembly of a RecA Nucleoprotein Filament that Can Overcome RecX Inhibition during Natural Chromosomal Transformation, Nucleic Acids Research 45(15): 8873-8885 (2017)
[10]. S. Le#, M. Yao#, J. Chen, A. K. Efremov, S. Azimi, and J. Yan*, Disturbance-free Rapid Solution Exchange for Magnetic Tweezers Single-molecule Studies, Nucleic Acids Research 43(17): e113 (2015)
[11]. S. Le, H. Chen, X. Zhang, J. Chen, K. Patil, K. Muniyappa*, and J. Yan*, Mechanical Force Antagonizes the Inhibitory Effects of RecX on RecA Filaments Formation in M. tuberculosis, Nucleic Acids Research 42 (19): 11992-11999. (2014)
[12]. H. Fu#, S. Le#, H. Chen, K. Muniyappa*, and J. Yan*, Force and ATP Hydrolysis Dependent Regulation of RecA Nucleoprotein Filament by Single-stranded DNA Binding Protein, Nucleic Acids Research 41, 924 (2013)
三、综述文章：
[1]. S. Le, M. Yu, A. Bershadsky*, and J.Yan*, Mechanical regulation of formin-dependent actin polymerization. Seminars In Cell & Developmental Biology 102: 73-80 (2020).
[2]. S. Le, M. Yu, and J. Yan*, Mechanical Regulation of Tension-transmission Supramolecular Linkages, Current Opinion in Solid State and Materials Science 25:100895 (2021).
招生方向: 生物物理、力学生物学、软凝聚态物理、生物材料等